Our fully vegan, 50 billion CFU (colony forming units), 14 strain probiotic blend contains carefully selected strains for you to thrive. Probiotics serve a multifactorial role in gut health, both helping balance and reduce intestinal permeability, as well as promoting the growth of healthy strains and supporting digestion. The science behind probiotics, gut health, and the gut-brain connection is vast and rapidly growing with over 1000+ studies performed on the efficacy of probiotics. Several studies have shown that supplementing with probiotics can reduce markers of intestinal permeability such as zonulin [1-8]. * Reducing intestinal permeability can reduce inflammation and improve cardiometabolic health [6, 13]. Furthermore, there is also evidence for the benefit of multi-strain probiotics on optimizing immune function [7, 28].* It has been shown that variations in microbial balances between healthy and unhealthy guts also play a role in mental health, mood, focus, and cognitive function through their effects on the gut-brain axis [8-20].* Probiotics can also help alleviate symptoms of gut imbalances, indigestion, bloating, abdominal discomfort, and cramping [20-28]. *
Quercetin is an antioxidant, flavanol, and polyphenol found in leafy greens, berries, broccoli, apples, green tea, and grapes. Quercetin has a range of benefits for your health and your gut bacteria. Quercetin promotes gut bacterial diversity by providing fuels for good bacteria to metabolize while also strengthening intestinal barrier function [29-30].* Quercetin is metabolized by your gut bacteria into phenolic acids, which are potent antioxidant compounds that benefit your health [31-35].* As an antioxidant, quercetin can quench free radicals in the body protecting cells from oxidative damage and support cardiovascular health [36-37].* Quercetin can also promote healthy aging through several mechanisms including the reduction of advanced glycation end-products and effects on aged, senescent cells [38-41].*
L-glutamine, an amino acid, is a crucial component of our formula. Evidence shows that glutamine plays a vital role in the strength of your intestinal barrier and intestinal permeability. It does this by regulating tight junction proteins (which keep bacteria from leaking into the bloodstream), promoting the proliferation of enterocytes (the cells that line your intestines), and reducing the inflammatory cascades caused by bacterial translocation across leaky intestines [46-61].* L-glutamine also promotes overall healthy digestion and GI health [62-64].*
This vibrant red extract from the fruit of pomegranates is abundant in healthy polyphenols, antioxidants, and gut nourishing nutrients that make it a crucial component of our comprehensive gut health formula. Pomegranate extract is rich in Ellagitannins, important bioactive polyphenols, including one of nature's largest polyphenols, Punicalagin. As your gut bacteria process the ellagitannins, they produce urolithins with positive brain supporting benefits [67-69].* Pomegranate extract also promotes the growth of beneficial gut bacteria and enhances bacterial diversity in the gut [65-71].* Furthermore, pomegranate extract promotes healthy and vital skin and reduces oxidative stress throughout the body.*
Artichoke Leaf Extract
Artichoke Extract is rich in beneficial compounds like inulin, luteolin, cynarin, and cynaropicrin. Artichoke extract is a rich prebiotic fiber, abundant in inulin which helps balance your gut flora. Prebiotic fibers are crucial for allowing healthy strains of bacteria and probiotics to flourish. Specifically, Artichoke supports the growth of beneficial strains of bacteria (like bifidobacteria and lactobacilli) while inhibiting the growth of harmful strains [72-73]. *
Artichoke extract can also be beneficial for overall GI and digestive health [74-78].* Further effects of artichoke extract include beneficial effects of artichokes on cardiovascular health, liver health, and nitric oxide production [79-94].*
Short-chain fructooligosaccharides (FOS) are a form of soluble fiber naturally found in chicory, asparagus, tomatoes, and more. In the intestines, FOS are metabolized by your gut bacteria into fuels and gut nourishing compounds like short-chain carboxylic acids. FOS are also considered prebiotics, which supports and stimulates healthy gut microbiota growth and function [94-97]. *
Additionally, FOS can have beneficial effects on mineral absorption and bioavailability; they can increase calcium absorption and promote stronger bones as well as bone mineral density [98-102]. *
BioPerine, a patented piperine extract, is a clinically proven enhancer of bioavailability and absorption
made by Sabinsa Corporation.* A crucial component of our formula, BioPerine maximizes your absorption and digestion of the compounds and vitamins our blends contain.* BioPerine is the only source of piperine that has been extensively clinically studied for safety and efficacy. It enhances the absorption of vitamins A, B complex, C, D, E, K, amino acids, antioxidants, herbal extracts, and more.*
Nu-Mag and Nu-Flow
Firm in our commitment to pure, quality non-GMO supplements, as well as environmental protection and sustainability, we use Nu-Mag and Nu-Flow in our PeakBiotic formula. Nu-Mag is used as a pure alternative to magnesium stearate and stearic acid, both of which are commonly derived from chemically sprayed GMO cottonseed oils and environmentally damaging palm oils.
Nu-Mag is made from four ingredients: rice concentrate, rice hull extract, gum arabica, and sunflower oil. Nu-Flow, known as the âsynthetics replacer,â replaces anti-caking agents with a rice hull concentrate naturally rich in silica.
Scientific references: please go to myPEAKs Website for the list of studies used.